Thionyl Chloride → HCID 11033045、化合物
反応式
[CH3:1][C:2]1[C:7]2[C:8](=[O:14])[N:9]([CH3:13])[S:10](=[O:12])(=[O:11])[C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]([OH:17])=O.S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1>[CH3:13][N:9]1[C:8](=[O:14])[C:7]2[C:6](=[CH:5][CH:4]=[C:3]([C:15]([Cl:20])=[O:17])[C:2]=2[CH3:1])[S:10]1(=[O:12])=[O:11]参加物
4
反応条件
- 温度
- 80 °C
実験手順
3.8 g (14.9 mmol) of 4,N-dimethyl-1,1,3-trioxo-2,3-dihydro-1λ6 benz[d]isothiazole-5-carboxylic acid are suspended in 100 ml of toluene, and the mixture is heated to 80° C. and 3.5 g (29.8 mmol) of thionyl chloride are added dropwise. After refluxing for two hours, the solution is decanted hot and the reaction mixture is concentrated on a rotary evaporator. Yield: 74% of theory, m.p.: 149°-150° C.
後処理
- temperatureAfter refluxing for two hours
- customthe solution is decanted hot
- concentrationthe reaction mixture is concentrated on a rotary evaporator
出典と根拠
- ORDレコード
- ord-6dc2b0703755493b899a4786f1fd7f7a
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05863864
反応ノート
読み込み中…