Hydrochloric Acid → HCID 54321377、化合物

HRID 343796ノート

反応式

HRID 343796 の反応式
[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54103043HCID 54103043、化合物

生成物 1

HCID 54321377HCID 54321377、化合物収率 84%

実験手順

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxy-quinoxaline (12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH 3) and the solid which precipitated was filtered off, washed with water and ether, and dried under reduced pressure at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, mp 225°-227° C.

後処理

  1. customthe solid which precipitated
  2. filtrationwas filtered off
  3. washwashed with water and ether
  4. customdried under reduced pressure at 80° C.

出典と根拠

ORDレコード
ord-0bde8bca09f74ff387dcb8abd6109cee
出典データセット
uspto-grants-1999_01
特許番号
US05863917

反応ノート

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