(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole → (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine

HRID 343898

反応式

HRID 343898 の反応式
O=C1[NH:6][CH:5]([CH2:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[C:4](=[O:24])N1.[OH2:25].[OH-].[Ba+2].[OH-]>O>[CH3:23][N:20]1[CH2:21][CH2:22][CH:17]([C:11]2[C:10]3[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][C@@H:5]([C:4]([OH:24])=[O:25])[NH2:6])[CH:9]=3)[NH:13][CH:12]=2)[CH2:18][CH2:19]1

参加物

4

反応物 2

HCID 15233277(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indoleHCID 17749100Barium hydroxide, monohydrate

生成物 1

HCID 22852202(+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of the product from step (d) (2.4 g) and barium hydroxide hydrate (8.4 g) in water (50 ml) was refluxed for 72 hours, then cooled and evaporated in vacuo. The residue was taken up in hot methanol and filtered to remove barium salts.

後処理

  1. temperaturecooled
  2. customevaporated in vacuo
  3. filtrationfiltered
  4. customto remove barium salts

出典と根拠

ORDレコード
ord-318bfde53829421087aea779f67bc012
出典データセット
uspto-grants-1999_01
特許番号
US05863935

関連ノート

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