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(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole → (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole | HCID 15233277 | — |
| 反応物 | Barium hydroxide, monohydrate | HCID 17749100 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine | HCID 22852202 | — |
反応手順
A solution of the product from step (d) (2.4 g) and barium hydroxide hydrate (8.4 g) in water (50 ml) was refluxed for 72 hours, then cooled and evaporated in vacuo. The residue was taken up in hot methanol and filtered to remove barium salts.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05863935 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-318bfde53829421087aea779f67bc012 |
| 出典メモ | uspto-grants-1999_01 |