Zolmitriptan → 3-Des[2-(Dimethylamino)ethyl] Zolmitriptan Acetonitrile
反応式
C[N:2]([CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][C@H:16]3[CH2:20][O:19][C:18](=[O:21])[NH:17]3)[CH:13]=2)[NH:8][CH:7]=1)C>C(Cl)(Cl)Cl>[C:4]([CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][C@H:16]3[CH2:20][O:19][C:18](=[O:21])[NH:17]3)[CH:13]=2)[NH:8][CH:7]=1)#[N:2]参加物
3
実験手順
A solution of the product from step (b) (2.5 g) and polyphosphate ester (20.0 g) in chloroform (40 ml) was refluxed for 20 minutes. Ice was added to the cooled mixture and the chloroform evaporated in vacuo. The remaining aqueous phase was extracted with ethyl acetate and the combined extracts evaporated in vacuo to give the desired product as a pale yellow oil (1.8 g).
後処理
- additionIce was added to the cooled mixture
- customthe chloroform evaporated in vacuo
- extractionThe remaining aqueous phase was extracted with ethyl acetate
- customthe combined extracts evaporated in vacuo
出典と根拠
- ORDレコード
- ord-63574b24f08040b983c7e8b1e3350c7d
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05863935
反応ノート
読み込み中…