Nitric Acid → HCID 54388458、化合物

HRID 343951

反応式

HRID 343951 の反応式
[NH2:1][CH:2]([C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([OH:13])[CH:7]=1)[C:3]([OH:5])=[O:4].[N+:14]([O-])([OH:16])=[O:15].[OH-].[Na+]>O>[NH2:1][CH:2]([C:6]1[CH:7]=[C:8]([OH:13])[CH:9]=[C:10]([OH:12])[C:11]=1[N+:14]([O-:16])=[O:15])[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 1080013,5-Dihydroxyphenylglycine

生成物 1

HCID 54388458HCID 54388458、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
-10 °C

実験手順

2-Amino-2-(3,5-dihydroxyphenyl)-acetic acid (183 mg, 1 mmol) was added portionwise to stirred 5.5M nitric acid (2.5 ml, 15 mmol), which has been cooled to -10° C. in an ice/salt bath. The resulting brown solution was diluted with water (2 ml), neutralised with 2M sodium hydroxide, and purified by cationic exchange chromatography (as in Example 14) to give the title compound as a fluffy yellow solid, m.p. >280° C.

後処理

  1. custompurified by cationic exchange chromatography (as in Example 14)

出典と根拠

ORDレコード
ord-d8b3701b5ba949b5bff96f29c7dfe01c
出典データセット
uspto-grants-1999_01
特許番号
US05863947

関連ノート

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