Diethyl (4-chloro-2-nitroanilino)methylphosphonate → Diethyl (2-amino-4-chloroanilino)methylphosphonate

HRID 343988

反応式

HRID 343988 の反応式
[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[N+:18]([O-])=O)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[H][H]>C(O)C.[Pt]>[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[NH2:18])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

参加物

5

反応物 2

HCID 603785Diethyl (4-chloro-2-nitroanilino)methylphosphonateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 592810Diethyl (2-amino-4-chloroanilino)methylphosphonate

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 702Ethanol溶媒

実験手順

A solution of [(4-Chloro-2-nitro-phenylamino)-methyl]-phosphonic acid diethyl ester (45g, 0.139 moles) in ethanol (500 mL) was treated under nitrogen at once with 5% Platinum on carbon (1.125 g) and then hydrogenated at 30° C. until the hydrogen uptake ceased. After purging the reaction vessel with nitrogen the reaction mixture was filtered through solka floc. The filter cake was washed with ethanol (100 mL) and the filtrate was used as such for next step without purification.

後処理

  1. customAfter purging the reaction vessel with nitrogen the reaction mixture
  2. filtrationwas filtered through solka floc
  3. washThe filter cake was washed with ethanol (100 mL)
  4. customwithout purification

出典と根拠

ORDレコード
ord-31dbc0ac1def464896ff979474a6b51b
出典データセット
uspto-grants-1999_01
特許番号
US05864040

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