Ethyl 2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetate → 2-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol

HRID 344026ノート

反応式

HRID 344026 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][C:14](OCC)=[O:15].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][CH2:14][OH:15]

参加物

4

反応物 2

HCID 10538520Ethyl 2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 106083702-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol収率 100.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A suspension of ethyl (5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)acetate (1.02 g) and lithium aluminum hydride (0.20 g) in tetrahydrofuran (15 ml was stirred at 0° C. for 2.5 hours. The solution was poured into cold 1N-hydrochlorlc acid, then the resulting mixture was filtered through the celite, and extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo to afford 2-(5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol as a colorless oil (0.85 g).

後処理

  1. additionThe solution was poured into cold 1N-hydrochlorlc acid
  2. filtrationthe resulting mixture was filtered through the celite
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-b8716bf5d6c94ce5863f698aa20b58da
出典データセット
uspto-grants-1999_01
特許番号
US05863918

反応ノート

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