Methyl iodide → 1-Methyl-3-(5-methyloxazol-2-yl)-pyridinium iodide

HRID 344693ノート

反応式

HRID 344693 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[I:13][CH3:14]>C(O)C>[I-:13].[CH3:14][N+:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[O:6][C:2]([CH3:1])=[CH:3][N:4]=2)[CH:8]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 196125075-Methyl-2-(3-pyridyl)-oxazole

生成物 1

HCID 679250801-Methyl-3-(5-methyloxazol-2-yl)-pyridinium iodide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5 g of 3-(5-methyloxazol-2-yl)-pyridine prepared as indicated in Chimica Therap 4, 437 (1973) is dissolved in 50 cm3 of ethanol, 3 cm3 of iodomethane is added and the whole is heated under reflux for 10 hours. After cooling and decanting, ether is added, and after filtering, 8.68 g of product is obtained. M.p.=147°-148° C., after crystallization from ethanol.

後処理

  1. temperaturethe whole is heated
  2. temperatureunder reflux for 10 hours
  3. temperatureAfter cooling
  4. customdecanting
  5. additionether is added
  6. filtrationafter filtering

出典と根拠

ORDレコード
ord-51fd0243d6b04062a1810d51847ac00e
出典データセット
uspto-grants-1991_10
特許番号
US05053416

反応ノート

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