2,2-Dimethoxypropane → HCID 178450587、化合物

HRID 344760

反応式

HRID 344760 の反応式
[CH3:1][C:2]([C@@H:6]([OH:36])[C:7]([NH:9][CH2:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][S:17][S:18][CH2:19][CH2:20][NH:21][C:22]([CH2:24][CH2:25][NH:26][C:27]([C@H:29]([OH:35])[C:30]([CH2:33][OH:34])([CH3:32])[CH3:31])=[O:28])=[O:23])=[O:13])=[O:8])([CH2:4][OH:5])[CH3:3].C[O:38][C:39](OC)([CH3:41])[CH3:40]>FC(F)(F)C(O)=O.CC(C)=O>[CH3:3][C:2]([C@@H:6]([OH:36])[C:7]([NH:9][CH2:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][S:17][S:18][CH2:19][CH2:20][NH:21][C:22]([CH2:24][CH2:25][NH:26][C:27]([C@H:29]([OH:35])[C:30]([CH2:33][OH:34])([CH3:31])[CH3:32])=[O:28])=[O:23])=[O:13])=[O:8])([CH2:4][OH:5])[CH3:1].[CH2-:40][C:39]([CH3:41])=[O:38]

参加物

5

反応物 2

HCID 64952,2-DimethoxypropaneHCID 452306Pantethine

生成物 1

HCID 178450587HCID 178450587、化合物

試薬・触媒・溶媒 2

HCID 6422Trifluoroacetic acid触媒HCID 180Acetone溶媒

実験手順

A mixture of 1.0 g of D-pantethine, 5 ml of 2,2-dimethoxypropane, 5 drops of trifluoroacetic acid and 5 ml of acetone was stirred for 2 days and then evaporated. The resulting white foam was purified by flash chromatography [dichloromethane:methanol (10:1)], giving 1.0 g of the desired compound as a white hygroscopic foam.

後処理

  1. customevaporated
  2. customThe resulting white foam was purified by flash chromatography [dichloromethane:methanol (10:1)]

出典と根拠

ORDレコード
ord-a9172500eed94a9897f37371b92ae604
出典データセット
uspto-grants-1991_10
特許番号
US05053426

関連ノート

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