Methyl p-toluenesulfonate → 1,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonate

HRID 344782

反応式

HRID 344782 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1.[C:9]1([CH3:20])[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>CC(C)=O>[C:9]1([CH3:20])[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:16])=[O:17])=[CH:13][CH:14]=1.[CH3:1][N+:2]1([CH3:9])[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1

参加物

4

反応物 2

HCID 6645Methyl p-toluenesulfonateHCID 980163-Piperidinol, 1-methyl-

生成物 1

HCID 150522081,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonate収率 164.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In 20 ml of acetone was dissolved 2.30 g of 1-methyl-3-piperidinol, and 3.72 g of methyl p-toluenesulfonate was added dropwise to the resulting solution. The mixture was stirred at room temperature, heated under reflux, and cooled to precipitate crystals. The crystals were collected by filtration and dried to give 4.94 g of the desired product, m.p. 125°-127° C. (decomp.).

後処理

  1. additionwas added dropwise to the resulting solution
  2. temperatureheated
  3. temperatureunder reflux
  4. temperaturecooled
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration
  7. customdried

出典と根拠

ORDレコード
ord-250ba9a0ebc94da1951455139c8420cc
出典データセット
uspto-grants-1991_10
特許番号
US05053402

関連ノート

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