Bromine → 2-Bromo-4-ethylphenol

A solution was prepared by dissolving 105 g of 4-ethylphenol into 500 ml of chloroform. The solution was cooled by ice water bath, followed by dropwise addition of 45 ml of bromine while stirring. The addition was took 1 hour. Then, the reaction mixture was cooled by an ice water bath while stirring for 4 hours, moved into a separatory funnel to wash with water, an aqueous solution saturated with NaCl, 10% water solution of sodium hydrogencarbonate and an aqueous solution saturated with NaCl in turn, and dried with magnesium sulfate anhydride. The solvent in the reactant was distilled off under reduced pressure to yield 173 g of light brown and oily 2-bromo-4-ethylphenol.

1. customA solution was prepared
2. temperatureThe solution was cooled by ice water bath
3. additionThe addition
4. temperatureThen, the reaction mixture was cooled by an ice water bath
5. stirringwhile stirring for 4 hours
6. custommoved into a separatory funnel
7. washto wash with water
8. dry with materialan aqueous solution saturated with NaCl, 10% water solution of sodium hydrogencarbonate and an aqueous solution saturated with NaCl in turn, and dried with magnesium sulfate anhydride
9. distillationThe solvent in the reactant was distilled off under reduced pressure

ORDレコード

ord-c6946c29b9434897a7e6e019ab9f0653

出典データセット

uspto-grants-1991_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05053548