4-((Dimethylamino)methyl)benzonitrile → HCID 19993416、化合物

HRID 344994ノート

反応式

HRID 344994 の反応式
[CH:1]1[C:18]2[C:5](=[C:6]([C:19]3[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=3)[CH2:22][Br:23])[C:7]3[C:16]([CH:17]=2)=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=3)[CH:4]=[CH:3][CH:2]=1.[CH3:27][N:28]([CH2:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][CH:32]=1)[CH3:29].[PH4+].[AsH4+]>C(#N)C.C(OCC)C>[Br-:23].[C:37]([C:34]1[CH:33]=[CH:32][C:31]([CH2:30][N+:28]([CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[C:19]([C:6]3[C:7]4[C:16](=[CH:15][C:14]5[C:9]([CH:8]=4)=[CH:10][CH:11]=[CH:12][CH:13]=5)[CH:17]=[C:18]4[C:5]=3[CH:4]=[CH:3][CH:2]=[CH:1]4)[CH:20]=2)([CH3:27])[CH3:29])=[CH:36][CH:35]=1)#[N:38]

参加物

7

反応物 4

HCID 8263294-((Dimethylamino)methyl)benzonitrileHCID 5460504PhosphoniumHCID 5460506ArsoniumHCID 19993410HCID 19993410、化合物

生成物 1

HCID 19993416HCID 19993416、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6342Acetonitrile溶媒

実験手順

A mixture of (B) and N,N-dimethyl-4-cyanobenzylamine in acetonitrile was refluxed for 2 hr. The reaction mixture was then poured into diethyl ether, and the crude product was collected by filtration. The crude product was recrystallized from ethanol. The same reaction can be used to prepare the corresponding phosphonium and arsonium salts.

後処理

  1. temperaturewas refluxed for 2 hr
  2. filtrationthe crude product was collected by filtration
  3. customThe crude product was recrystallized from ethanol
  4. customThe same reaction

出典と根拠

ORDレコード
ord-170f77478cd344a1a077d6f87d7c2d30
出典データセット
uspto-grants-1991_10
特許番号
US05055376

反応ノート

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