Methanesulfonyl chloride → N-Ethyl-N-(6-methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine hydrochloride

HRID 345026ノート

反応式

HRID 345026 の反応式
[CH3:1][S:2]([Cl:5])(=[O:4])=[O:3].[CH2:6]([N:8]([CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:25][CH:24]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([NH2:20])[CH:16]=2)[N:11]=1)[CH3:7]>N1C=CC=CC=1>[ClH:5].[CH2:6]([N:8]([CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][S:30]([CH3:33])(=[O:31])=[O:32])=[CH:25][CH:24]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([NH:20][S:2]([CH3:1])(=[O:4])=[O:3])[CH:16]=2)[N:11]=1)[CH3:7]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 19813422N-ethyl-N-(6-aminoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine

生成物 1

HCID 19813440N-Ethyl-N-(6-methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine hydrochloride

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Methanesulphonyl chloride (0.1 g, 1.29 mmole) was reacted with N-ethyl-N-(6-aminoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine (see Preparation 11B - 0.51 g, 1.23 mmole) in pyridine similarly to the procedure of Example 2, giving the free base of the title compound as a gum. The gum was dissolved in ethyl acetate and the solution was diluted with ethereal hydrogen chloride and evaporated to dryness. The residue was triturated with ether to give the title compound as a foam, yield 0.06 g, m.p. 96°.

出典と根拠

ORDレコード
ord-848b0ac6718a40379e42ee16b4c042e4
出典データセット
uspto-grants-1991_10
特許番号
US05055473

反応ノート

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