2-Methyl-6-nitroquinoline → 2-Methylquinolin-6-amine

HRID 345041

反応式

HRID 345041 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-])=O)[CH:8]=2)[N:3]=1>C(O)C.[Pd]>[NH2:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([CH3:1])[CH:11]=[CH:10]2

参加物

4

反応物 1

HCID 691722-Methyl-6-nitroquinoline

生成物 1

HCID 1031482-Methylquinolin-6-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-Methyl-6-nitroquinoline (18.8 g) was stirred under a hydrogen atmosphere at 30 p.s.i. (equivalent to 206. 8 kPa) for 2 hours in ethanol solution containing 5% Pd/C. The catalyst was then removed by filtration, the filtrate evaporated to small volume in vacuo, and the resultant precipitate collected by filtration, washed with ethanol and ether, and dried to give the title compound, yield 13.2 g, m.p. 188°-189°.

後処理

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate evaporated to small volume in vacuo
  3. filtrationthe resultant precipitate collected by filtration
  4. washwashed with ethanol and ether
  5. customdried

出典と根拠

ORDレコード
ord-11ff7ed9f41c4091876e3ffef802b25a
出典データセット
uspto-grants-1991_10
特許番号
US05055473

関連ノート

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