Methanesulfonyl chloride → N-(2-Methylquinolin-6-yl)methanesulfonamide

HRID 345042

反応式

HRID 345042 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2)(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 1031482-Methylquinolin-6-amine

生成物 1

HCID 19813426N-(2-Methylquinolin-6-yl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.

後処理

  1. temperaturecooled to 5°
  2. customThe pyridine was then removed by evaporation in vacuo
  3. additionthe residue diluted with aqueous sodium bicarbonate
  4. extractionextracted three times with methylene chloride
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-791cb89a953e43a6977715154fc64535
出典データセット
uspto-grants-1991_10
特許番号
US05055473

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