Trimethyl orthoformate → HCID 11008070、化合物

HRID 345209

反応式

HRID 345209 の反応式
[OH:1][CH2:2][C:3](C)([CH3:6])[CH:4]=O.[CH:8]([O:13][CH3:14])([O:11][CH3:12])OC.Cl.O1CCOCC1.O(C)[Na]>CO>[CH3:14][O:13][CH:8]([O:11][CH3:12])[C:3]([CH3:6])([CH3:4])[CH2:2][OH:1]

参加物

6

反応物 4

HCID 9005Trimethyl orthoformateHCID 116993-Hydroxy-2,2-dimethylpropionaldehydeHCID 204431481,4-Dioxane hydrochlorideHCID 178418582HCID 178418582、化合物

生成物 1

HCID 11008070HCID 11008070、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 24.4 g (0.24 mol) of 3-hydroxy-2,2-dimethylpropanal (Aldrich), 26 g (0.25 mol) of trimethyl orthoformate, and 0.5 mL of 6.8 N HCl/dioxane in 300 mL of methanol was allowed to stand at room temperature overnight. A slight excess of NaOCH3 was added and the solvent evaporated at reduced pressure. The residue was dissolved in ether and the mixture filtered. After evaporation of solvent and fractionation twice through a 15 cm Vigreux column, the product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%).

後処理

  1. customthe solvent evaporated at reduced pressure
  2. dissolutionThe residue was dissolved in ether
  3. filtrationthe mixture filtered
  4. customAfter evaporation of solvent and fractionation twice through a 15 cm Vigreux column
  5. customthe product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%)

出典と根拠

ORDレコード
ord-2c753e33e993440b831c89dc3bb7c67a
出典データセット
uspto-grants-1991_10
特許番号
US05055613

関連ノート

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