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Trimethyl orthoformate → HCID 11008070、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | 3-Hydroxy-2,2-dimethylpropionaldehyde | HCID 11699 | — |
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 反応物 | HCID 178418582 | HCID 178418582 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 11008070 | HCID 11008070 | — |
反応手順
A solution of 24.4 g (0.24 mol) of 3-hydroxy-2,2-dimethylpropanal (Aldrich), 26 g (0.25 mol) of trimethyl orthoformate, and 0.5 mL of 6.8 N HCl/dioxane in 300 mL of methanol was allowed to stand at room temperature overnight. A slight excess of NaOCH3 was added and the solvent evaporated at reduced pressure. The residue was dissolved in ether and the mixture filtered. After evaporation of solvent and fractionation twice through a 15 cm Vigreux column, the product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05055613 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-2c753e33e993440b831c89dc3bb7c67a |
| 出典メモ | uspto-grants-1991_10 |