Water → 1-Pyrrolidino-1-cyclohexene

HRID 345308

反応式

HRID 345308 の反応式
[C:1]1(=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.O>C1C=CC=CC=1>[N:8]1([C:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=2)[CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

5

反応物 3

HCID 962WaterHCID 7967CyclohexanoneHCID 31268Pyrrolidine

生成物 1

HCID 707681-Pyrrolidino-1-cyclohexene収率 95.9%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Cyclohexanone (196.3 g) and pyrrolidine (214 g) in benzene (500 ml) were refluxed under nitrogen with a Dean-Stark apparatus, until no more water separated out. The solvents were then evaporated off under nitrogen, and the residual oil was distilled to give 1-(1-pyrrolidinyl)cyclohexene (290 g).

後処理

  1. customseparated out
  2. customThe solvents were then evaporated off under nitrogen
  3. distillationthe residual oil was distilled

出典と根拠

ORDレコード
ord-cf667839892a418383ce21ec62dc57f8
出典データセット
uspto-grants-1991_10
特許番号
US05057513

関連ノート

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