Water → 2-Benzylcyclohexan-1-one

HRID 345309

反応式

HRID 345309 の反応式
N1([CH:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)CCCC1.[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH2:20]>O1CCOCC1>[C:13]1([CH2:12][CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]2=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 7503Benzyl ChlorideHCID 139064Pyrrolidine, 1-cyclohexyl-

生成物 1

HCID 989452-Benzylcyclohexan-1-one

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 1-(1-pyrrolidinyl)cyclohexane (85.4 g) and benzyl chloride (100 ml) in dioxane (400 ml) was heated under reflux for 23 hours under nitrogen. Water (100 ml) was then added and the brown oil was distilled to give (2RS)-2-phenylmethylcyclohexanone (47.1 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 23 hours under nitrogen
  3. distillationthe brown oil was distilled

出典と根拠

ORDレコード
ord-21da1710588a4bcabd47799acedec4b2
出典データセット
uspto-grants-1991_10
特許番号
US05057513

関連ノート

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