Triethylamine → HCID 178507339、化合物

HRID 345406ノート

反応式

HRID 345406 の反応式
[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:8]3=[N:13]O[N:15]=[C:7]3[CH:6]=[CH:5][C:4]=2[N:3]=1.C(N(CC)CC)C>CN(C)C=O.[Pd]>[NH2:13][C:8]1[C:7]([NH2:15])=[CH:6][CH:5]=[C:4]2[C:9]=1[N:10]=[C:11]([OH:12])[C:2]([OH:1])=[N:3]2

参加物

5

反応物 2

HCID 8471TriethylamineHCID 178517014HCID 178517014、化合物

生成物 1

HCID 178507339HCID 178507339、化合物収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 5,0 g (24,5 mmol) 7,8-dihydroxy-1,2,5-oxadiazolo(3,4-f)quinoxaIine and 6,8 ml (49 mmol) triethylamine in 500 ml dimethylformamide was hydrogenated at atm. pressure using 5% Pd-C (0,5 g) as a catalyst. The reaction mixture was filtered and evaporated in vacuo. The residue was stirred with water, and the precipitate was filtered off to give 4,5 g (96%) 5,6-diamino-2,3-dihydroxyquinoxaline, m.p. >300° C. NMR (DMSO-d6) 11.0 (2H, broad m), 6.43 (1H,d), 6.23 (1H,d), 4.5 (4H, broad m).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customevaporated in vacuo
  3. filtrationthe precipitate was filtered off

出典と根拠

ORDレコード
ord-7b2f1a4780724616b5c3cba4048746f6
出典データセット
uspto-grants-1991_10
特許番号
US05057516

反応ノート

読み込み中…