Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

HRID 34578

反応式

HRID 34578 の反応式
[Cl:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]([CH3:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O-]S(S([O-])=O)=O.[Na+].[Na+].Cl>COCCO.O>[NH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[C:8]([F:15])[C:9]=1[CH3:14])[C:4]([OH:6])=[O:5]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 24489Sodium DithioniteHCID 136574392-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

生成物 1

HCID 136574403-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 80192-Methoxyethanol溶媒

実験手順

18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.

後処理

  1. temperaturecooled
  2. customThe solid which has precipitated
  3. customis isolated
  4. customdried

出典と根拠

ORDレコード
ord-59d9ecf81f1c4d51bdbef875b42cf00b
出典データセット
uspto-grants-1988_08
特許番号
US04762844

関連ノート

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