Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione → 6-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine

HRID 345804

反応式

HRID 345804 の反応式
[CH2:1]([N:8]1[C:16](=O)[CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][CH2:14]2)[C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][CH2:14]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 9899604Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dioneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 113563766-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

44 g (about 0.18 mol) of crude or pure 6-benzyl-5,7-dioxo-octahydropyrrolo[3,4-b]pyridine are reduced with 15.2 g (0.40 mol) of lithium aluminum hydride in 390 ml of absolute tetrahydrofuran in the course of 10 hours in accordance with the working instructions of Example Ic. 24.4 g of a colorless oil having a boiling point of 93°-95° C./0.06 mbar are obtained on distillation.

後処理

  1. customare obtained on distillation

出典と根拠

ORDレコード
ord-741b9a41322445a09c918eb2286fe4a5
出典データセット
uspto-grants-1991_10
特許番号
US05059597

関連ノート

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