Sulfuric Acid → 2-Chloro-4,5-dimethyl-3-nitro-benzoic acid
反応式
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[C:10]([N+:18]([O-:20])=[O:19])=[C:9]([CH3:11])[C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]参加物
4
実験手順
31.6 g of 2-chloro-4,5-dimethylbenzoic acid are initially introduced into 94 ml of H2SO4. 19 g of KNO3 are added in portions, while cooling with ice. The mixture is subsequently warmed to 50° for a further 2 hours and then poured onto ice. The product is isolated and recrystallized from toluene. Yield: 25.3 g, melting point: 160°-63°.
後処理
- temperaturewhile cooling with ice
- temperatureThe mixture is subsequently warmed to 50° for a further 2 hours
- additionpoured onto ice
- customThe product is isolated
- customrecrystallized from toluene
出典と根拠
- ORDレコード
- ord-25edcd85ecdb428288232c70d29b3d78
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04762844
反応ノート
読み込み中…