Potassium Carbonate → 1,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

HRID 345828ノート

反応式

HRID 345828 の反応式
C([N:4]1[CH2:11][C:10]2([CH3:12])[CH:6]([CH2:7][O:8][N:9]2[CH3:13])[CH2:5]1)(=O)C.[OH-].[Na+].C([O-])([O-])=O.[K+].[K+]>O>[CH3:12][C:10]12[CH2:11][NH:4][CH2:5][CH:6]1[CH2:7][O:8][N:9]2[CH3:13]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 150700177-Acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

生成物 1

HCID 150700181,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

11.8 g (64 mmol) of 7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane are heated under reflux with 12 g of NaOH in 36 ml of water overnight. The mixture is saturated with K2CO3 and extracted several times with CHCl3, the extract is dried over K2CO3 and concentrated and the residue is distilled.

後処理

  1. extractionextracted several times with CHCl3
  2. dry with materialthe extract is dried over K2CO3
  3. concentrationconcentrated
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-b9c6520b46094dc98b1ea6c72a4a8901
出典データセット
uspto-grants-1991_10
特許番号
US05059597

反応ノート

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