3-(2,4,5-Trifluorophenyl)prop-2-yn-1-ol → 3-(2,4,5-Trifluorophenyl)propan-1-ol

HRID 345895ノート

反応式

HRID 345895 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]#[C:11][CH2:12][OH:13]>C(OCC)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH2:10][CH2:11][CH2:12][OH:13]

参加物

4

反応物 1

HCID 199916063-(2,4,5-Trifluorophenyl)prop-2-yn-1-ol

生成物 1

HCID 199916093-(2,4,5-Trifluorophenyl)propan-1-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 3-(2,4,5-trifluorophenyl)prop-2-yn-1-ol (90 mg, 0.48 mmol) in diethyl ether (10 ml) was hydrogenated over 10% palladium on carbon at room temperature for 15 hours. The mixture was filtered through celite and the filtrate on evaporation gave an oil, which was flash chromatographed on silica using 10% ethyl ether/hexane. Fractions with Rf of about 0.16 on evaporation gave the title alcohol as a colorless oil.

後処理

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate on evaporation
  3. customgave an oil, which
  4. customchromatographed on silica using 10% ethyl ether/hexane
  5. customFractions with Rf of about 0.16 on evaporation

出典と根拠

ORDレコード
ord-2964f7ce8eaa4b838ec7af6274bf41a1
出典データセット
uspto-grants-1991_10
特許番号
US05059611

反応ノート

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