5-Fluoro-4-methyl-2-nitrobenzoic acid → 2-Amino-5-fluoro-4-methylbenzoic acid

HRID 34591ノート

反応式

HRID 34591 の反応式
[N+:1]([C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>O1CCOCC1.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 1

HCID 136574495-Fluoro-4-methyl-2-nitrobenzoic acid

生成物 1

HCID 136574502-Amino-5-fluoro-4-methylbenzoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 312751,4-Dioxane溶媒

実験手順

525 g of 2-nitro-4-methyl-5-fluoro-benzoic acid are hydrogenated in 3 l of dioxane with 50 g of 5% strength Pd-C catalyst at 30°-40° under 20-30 bar. The catalyst is filtered off with suction and the solution is poured onto water. The crystals which have precipitated are filtered off with suction and dried. Yield: 357 g (80.1% of theory), melting point: 201°-202° C.

後処理

  1. filtrationThe catalyst is filtered off with suction
  2. additionthe solution is poured onto water
  3. customThe crystals which have precipitated
  4. filtrationare filtered off with suction
  5. customdried

出典と根拠

ORDレコード
ord-e46f2afba65f4f8c8a73c8e0d2d83634
出典データセット
uspto-grants-1988_08
特許番号
US04762844

反応ノート

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