Ethylene → 1-(2-Bromoethyl)-3,5-dimethyl Adamantane

HRID 346102

反応式

HRID 346102 の反応式
Br[C:2]12[CH2:11][C:6]3([CH3:12])[CH2:7][CH:8]([CH2:10][C:4]([CH3:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Br-:14].[Al+3].[Br-].[Br-].[CH2:18]=[CH2:19]>CCCCCC>[Br:14][CH2:18][CH2:19][C:8]12[CH2:10][C:4]3([CH3:13])[CH2:3][CH:2]([CH2:11][C:6]([CH3:12])([CH2:5]3)[CH2:7]1)[CH2:9]2

参加物

5

反応物 3

HCID 6325EthyleneHCID 983171-Bromo-3,5-dimethyladamantaneHCID 166749Bromhydrol

生成物 1

HCID 150687671-(2-Bromoethyl)-3,5-dimethyl Adamantane収率 48%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Mix 1.4 mol of 1-bromo-3,5-dimethyl adamantane (I) in hexane with 0.6 mol of aluminum bromide at -75° C. Subsequently, pass ethylene through the solution for 20-30 minutes, stir for 5 min., and pour the reaction mixture onto ice water. Extract with ether, dry the organic phase and evaporate to dryness. Recrystallize the residue from methanol. (Yield: 48%).

後処理

  1. customfor 20-30 minutes
  2. additionpour the reaction mixture onto ice water
  3. extractionExtract with ether
  4. customdry the organic phase
  5. customevaporate to dryness
  6. customRecrystallize the residue from methanol

出典と根拠

ORDレコード
ord-8ea37ed7204243fe814166548c4d8d15
出典データセット
uspto-grants-1991_10
特許番号
US05061703

関連ノート

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