Bromine → 1-Bromo-3,5-dimethyl-7-ethyl Adamantane
反応式
[CH3:1][C:2]12[CH2:11][C:6]3([CH2:12][CH3:13])[CH2:7][CH:8]([CH2:10][C:4]([CH3:14])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Br:15]Br.S([O-])([O-])=O.[Na+].[Na+]>>[Br:15][C:8]12[CH2:10][C:4]3([CH3:14])[CH2:5][C:6]([CH2:12][CH3:13])([CH2:11][C:2]([CH3:1])([CH2:3]3)[CH2:9]1)[CH2:7]2参加物
4
実験手順
Mix 0.4 mol of 1,3-dimethyl-5-ethyl adamantane (III) with a ten times excess of bromine (4 mol). Heat slowly and stir for 4 hrs under reflux. Subsequently allow to cool and pour onto ice water. Decompose the excess bromine with sodium sulfite until discolouration of the aqueous solution. Then extract with ether, wash the combined organic phases with sodium bicarbonate solution, dry with magnesium sulfate, filter and evaporate to dryness under vacuum. Recrystallize the residue from methanol. (Yield: 86%).