Nitric Acid → 5-Chloro-2-ethoxalylamino-3-nitrobenzotrifluoride
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:14])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[N+:20]([O-])([OH:22])=[O:21]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:20]([O-:22])=[O:21])[C:5]([NH:12][C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:14])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1参加物
4
実験手順
To a solution of 2.4 g (8.1 mmol) 5-chloro-2-ethoxalylaminobenzotrifluoride in 13 ml 95-97% sulfuric acid a solution of 12 ml 100% nitric acid in 24 ml 95-97% sulfuric acid was added dropwise at 0°-5° C. Stirring was continued at 25° C. for 20 min. The reaction mixture was poured into 100 ml ice-water to give an oil. Extraction with dichloromethane gave 2.1 g (76%) of 5-chloro-2-ethoxalylamino-3-nitrobenzotrifluoride as crystals. M.p. 100°-101° C.