Acetic Acid → Methyl 4-carbamothioylbenzoate

HRID 346287

反応式

HRID 346287 の反応式
C(O)(=[S:3])C.[C:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=1)#[N:6].C(O)(=O)C>C(O)(C)C.O>[C:11]([C:10]1[CH:15]=[CH:16][C:7]([C:5](=[S:3])[NH2:6])=[CH:8][CH:9]=1)([O:13][CH3:14])=[O:12]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 70791Methyl 4-cyanobenzoateHCID 178418634HCID 178418634、化合物

生成物 1

HCID 11401319Methyl 4-carbamothioylbenzoate収率 77.7%

試薬・触媒・溶媒 1

HCID 21889133Propan-2-ol--water (1/1)溶媒

実験手順

130 g (1.7 moles) of thioacetic acid, 50 g (0.3 mole) of methyl 4-cyanobenzoate and 12 ml of glacial acetic acid were stirred for 2 hours at 80° C. The mixture was allowed to cool, 200 ml of 1:1 isopropanol/water was added, the mixture was stirred for a short time and the crystals formed were filtered off under suction. 45.5 g of 4-carbomethoxybenzothiamide of melting point 188°-190° C. were obtained in this manner.

後処理

  1. temperatureto cool
  2. customthe crystals formed
  3. filtrationwere filtered off under suction

出典と根拠

ORDレコード
ord-981319bd557c4bf2a449627f74850574
出典データセット
uspto-grants-1991_10
特許番号
US05061705

関連ノート

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