Sodium Hydroxide → 4-Thiazolecarboxylicacid,5-(ethylthio)-

HRID 34665ノート

反応式

HRID 34665 の反応式
[CH2:1]([S:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]C)=[O:10])[CH3:2].[OH-].[Na+]>CO.O>[C:9]([C:5]1[N:6]=[CH:7][S:8][C:4]=1[S:3][CH2:1][CH3:2])([OH:11])=[O:10]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 21298284Methyl 5-ethylthio-1,3-thiazole-4-carboxylate

生成物 1

HCID 136879364-Thiazolecarboxylicacid,5-(ethylthio)-収率 84.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

6 g of methyl 5-ethylthio-1,3-thiazole-4-carboxylate were dissolved in 100 ml of methanol and heated with 1.2 g of NaOH in 10 ml of water under reflux for about 1 h. After the solvent had been removed in a rotary evaporator, the solids were removed by filtration, and the filtrate was acidified with 2N HCl solution. After drying, 4.7 g of the title compound, of melting point 158°-9° C., were obtained.

後処理

  1. temperatureunder reflux for about 1 h
  2. customAfter the solvent had been removed in a rotary evaporator
  3. customthe solids were removed by filtration
  4. customAfter drying

出典と根拠

ORDレコード
ord-39bbea6fbf0a43e38301504dfc6c5430
出典データセット
uspto-grants-1988_08
特許番号
US04762848

反応ノート

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