反応式
Cl.CN(C(ON1N=N[C:12]2[CH:13]=[CH:14][CH:15]=[N:16][C:11]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH:26](N(C(C)C)CC)(C)[CH3:27].[C:35](=[O:38])(O)[O-:36].[Na+]>CN(C=O)C>[CH2:15]1[CH2:14][CH2:13][CH:12]([C@H:11]([NH2:16])[C:35]([OH:36])=[O:38])[CH2:27][CH2:26]1参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
HCl (1.717 g, 6.87 mmol), HATU (2.618 g, 6.89 mmol) and diisopropylethyl amine (4.00 mL, 23.0 mmol) were added to a solution of the compound from Example 1, step 2 (1.704 g, 6.24 mmol) in anhydrous DMF (10 mL) at RT. The reaction was stirred at RT for 2.5 h. The reaction was diluted with saturated aqueous sodium bicarbonate (50 mL) and extracted with ether (150+100 mL). The organic phases were washed with water (100+50 mL), dried (MgSO4) and concentrated in vacuo to give 2.994 g of a yellow oil.
後処理
- extractionextracted with ether (150+100 mL)
- washThe organic phases were washed with water (100+50 mL)
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-0b852f742e434fdf8128ea80219336fe
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07173046B2
関連ノート
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