Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate → HCID 15093271、化合物

HRID 34672ノート

反応式

HRID 34672 の反応式
[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([O:15]C(C)(C)C)=[O:14])([O:3][CH3:4])=[O:2]>FC(F)(F)C(O)=O>[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([OH:15])=[O:14])([O:3][CH3:4])=[O:2]

参加物

3

反応物 1

HCID 15093267Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate

生成物 1

HCID 15093271HCID 15093271、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

7.8 g of tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate are stirred in a mixture of 100 ml of trifluoroacetic acid and 100 ml of methylene ohloride at room temperature for 30 min. The solvent is removed in vacuo, and the residue is extracted by stirring with 100 ml of ether/petroleum ether (50°-70° C.) 1/1. After filtration and drying, 6.2 g of melting point 112°-116° C. are obtained, melting point 120°-121° C. after recrystallization from ethyl acetate.

後処理

  1. customThe solvent is removed in vacuo
  2. extractionthe residue is extracted
  3. filtrationAfter filtration
  4. customdrying
  5. custom6.2 g of melting point 112°-116° C. are obtained
  6. custommelting point 120°-121° C. after recrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-e56279be3e36461cb3c5171b1f57e0d3
出典データセット
uspto-grants-1988_08
特許番号
US04762848

反応ノート

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