Benzyl Bromide → 1-benzyl-2-methyl-2,3-dihydro-1H-indole

HRID 346842

反応式

HRID 346842 の反応式
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.C([O-])([O-])=O.[K+].[K+].[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[NH4+].[Cl-]>CN(C=O)C.CCOCC>[CH2:17]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH:2]1[CH3:1])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

7

反応物 4

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 233052-MethylindolineHCID 25517Ammonium Chloride

生成物 1

HCID 105135891-benzyl-2-methyl-2,3-dihydro-1H-indole収率 101.5%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 1 g (7.5 mmol) of 2-methyl-2,3-dihydro-1H-indole in anhydrous DMF were added 1.03 g (7.5 mmol) of K2CO3 and then dropwise 0.97 mL (8.0 mmol) of benzylbromide. The mixture was stirred at RT for 3hrs and then distributed between Et2O and a saturated aqueous solution of NH4Cl. The combined organic phases were dried over Na2SO4 and evaporated to yield 1.7 g (quantitative) of crude 1-benzyl-2-methyl-2,3-dihydro-1H-indole, light blue oil, MS: 224 (MH+).

後処理

  1. dry with materialThe combined organic phases were dried over Na2SO4
  2. customevaporated

出典と根拠

ORDレコード
ord-2a2f6613161d4ab09e81152c621626b0
出典データセット
uspto-grants-2007_02
特許番号
US07173048B2

関連ノート

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