Thionyl Chloride → 4-(3-Diethylaminopropoxy)benzoyl chloride
反応式
[CH2:1]([N:3]([CH2:17][CH3:18])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1)[CH3:2].S(Cl)([Cl:21])=O>C(Cl)Cl>[CH2:1]([N:3]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:21])=[O:13])=[CH:10][CH:9]=1)[CH2:17][CH3:18])[CH3:2]参加物
4
実験手順
A solution of the compound from Example 2(ii)(6 g, 24 mmol) in DCM was stirred at 0° C. Thionyl chloride was added drop-wise and the reaction was heated at reflux for 24 hrs. The reaction was allowed to cool and the solvents removed under vacuum to afford the expected compound as a pungent crude solid. 5.9 g, 100%. The solid was used without further purification.
後処理
- temperaturethe reaction was heated
- temperatureat reflux for 24 hrs
- temperatureto cool
- customthe solvents removed under vacuum
出典と根拠
- ORDレコード
- ord-8e2e87e7931545c7ac0028b3f0c20262
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07173061B2
反応ノート
読み込み中…