Water → 3-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

HRID 346890ノート

反応式

HRID 346890 の反応式
Cl.[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:16])[F:15])=[C:9]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH:8]=1.O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:15])[F:16])=[C:9]([O:17][CH2:18][CH:19]2[CH2:20][CH2:21]2)[CH:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 669202293-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt

生成物 1

HCID 588000783-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt (540 mg 1.5 mmol) in methylene chloride (20 ml) was added water (20 ml) and sodium carbonate (160 mg, 1.5 mmol). The mixture was stirred at room temperature for 30 min then separated in separatory funnel. The organic layer was washed with water (20 ml), brine (20 ml) and dried over magnesium sulfate. The solvent was removed in vacuo. The resulted oil was used in next step without further purification.

後処理

  1. customthen separated in separatory funnel
  2. washThe organic layer was washed with water (20 ml), brine (20 ml)
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was removed in vacuo
  5. customThe resulted oil was used in next step without further purification

出典と根拠

ORDレコード
ord-c59755ac04b04760a04835bcb50b721b
出典データセット
uspto-grants-2007_02
特許番号
US07173058B2

反応ノート

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