Potassium Carbonate → 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone

HRID 346984ノート

反応式

HRID 346984 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)=[O:19])[CH:16]=3)[N:11]=[C:10]([O:27]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>Cl.C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18](=[O:19])[C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)[CH:16]=3)[NH:11][C:10](=[O:27])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 21082028[4-(3-Chlorophenyl)-2-methoxy-6-quinolinyl](3-iodophenyl)-methanone

生成物 1

HCID 210820354-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone収率 88%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of intermediate (73) (0.0304 mol) in HCl 3N (150 ml) and THF (70 ml) was stirred and refluxed overnight, brought to room temperature, poured out into ice water and basified with potassium carbonate. The precipitate was filtered, washed with 2-propanone and dried, yielding 13 g (88%) of 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone (intermediate 74).

後処理

  1. temperaturerefluxed overnight
  2. custombrought to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with 2-propanone
  5. customdried

出典と根拠

ORDレコード
ord-df125b2042124c39917f6eb35422eafd
出典データセット
uspto-grants-2007_02
特許番号
US07173040B2

反応ノート

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