Methanol → (2-Fluoro-6-(trifluoromethyl)phenyl)methanamine

HRID 347766ノート

反応式

HRID 347766 の反応式
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[C:4]#[N:5].CO>C1COCC1>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:3]=1[CH2:4][NH2:5]

参加物

4

反応物 2

HCID 887MethanolHCID 1456132-Fluoro-6-(trifluoromethyl)benzonitrile

生成物 1

HCID 2774790(2-Fluoro-6-(trifluoromethyl)phenyl)methanamine収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To 2-fluoro-6-(trifluoromethyl)benzonitrile (45 g, 0.238 mmol) in 60 mL of THF was added 1 M BH3:THF slowly at 60° C. and the resulting solution was refluxed overnight. The reaction mixture was cooled to ambient temperature. Methanol (420 mL) was added slowly and stirred well. The solvents were then evaporated and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4. Evaporation gave 1a as a yellow oil (46 g, 0.238 mmol). MS (CI) m/z 194.0 (MH+).

後処理

  1. customThe solvents were then evaporated
  2. customthe residue was partitioned between EtOAc and water
  3. dry with materialThe organic layer was dried over Na2SO4
  4. customEvaporation

出典と根拠

ORDレコード
ord-2b2be5b5814442539d8edf7824c9f5b3
出典データセット
uspto-grants-2007_02
特許番号
US07176211B2

反応ノート

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