Methanol → Methyl (2-chlorophenyl)acetate

HRID 347780

反応式

HRID 347780 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]

参加物

4

反応物 2

HCID 887MethanolHCID 17124o-Chlorophenylacetic acid

生成物 1

HCID 93683Methyl (2-chlorophenyl)acetate収率 97.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5% ) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).

後処理

  1. temperaturethe solution was refluxed for 16 hours
  2. concentrationAfter concentration
  3. washwashed with sat'd aq. NaHCO3, H2O and brine
  4. dry with materialThe organic layer was dried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-3743fead2e244e8f877581d62ad96443
出典データセット
uspto-grants-2007_02
特許番号
US07176211B2

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