Ammonia → Oxane-4-carboxamide

HRID 347859

反応式

HRID 347859 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9]C)=O)[CH2:3][CH2:2]1.[NH3:11]>>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([NH2:11])=[O:9])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 222AmmoniaHCID 27735202H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

生成物 1

HCID 13197203Oxane-4-carboxamide収率 74.6%

実験手順

Concentrated aqueous ammonia (50 mL) was added to methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) and the reaction mixture was stirred for 43.5 hours at room temperature. The reaction mixture was then cooled in an ice water bath, after which the precipitate was filtered out and dried under reduced pressure at 40° C. to afford 33.4 g of the title compound (74.6% yield).

後処理

  1. temperatureThe reaction mixture was then cooled in an ice water bath
  2. filtrationafter which the precipitate was filtered out
  3. customdried under reduced pressure at 40° C.

出典と根拠

ORDレコード
ord-252e002dbf1d499fbd2f04606d198237
出典データセット
uspto-grants-2007_02
特許番号
US07176216B2

関連ノート

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