Dabco → 1-[4'-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]4-oxoazetidin-2-yl}phenoxymethyl)biphenyl-4-ylmethyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide

HRID 348050

反応式

HRID 348050 の反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[N:26]([C:27]5[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=5)[C:25](=[O:34])[CH:24]4[CH2:35][CH2:36][CH:37]([C:39]4[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=4)[OH:38])=[CH:19][CH:18]=3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[CH2:46]1[N:51]2[CH2:52][CH2:53][N:48]([CH2:49][CH2:50]2)[CH2:47]1>C1(C)C=CC=CC=1>[Br-:1].[F:33][C:30]1[CH:31]=[CH:32][C:27]([N:26]2[C:25](=[O:34])[CH:24]([CH2:35][CH2:36][CH:37]([C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)[OH:38])[CH:23]2[C:20]2[CH:21]=[CH:22][C:17]([O:16][CH2:15][C:12]3[CH:13]=[CH:14][C:9]([C:6]4[CH:5]=[CH:4][C:3]([CH2:2][N+:48]56[CH2:53][CH2:52][N:51]([CH2:50][CH2:49]5)[CH2:46][CH2:47]6)=[CH:8][CH:7]=4)=[CH:10][CH:11]=3)=[CH:18][CH:19]=2)=[CH:28][CH:29]=1

参加物

4

反応物 2

HCID 9237DabcoHCID 210831914-[4-(4'-Bromomethylbiphenyl-4-ylmethoxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one

生成物 1

HCID 210831591-[4'-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]4-oxoazetidin-2-yl}phenoxymethyl)biphenyl-4-ylmethyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Compound (21) and DABCO were dissolved in toluene and reacted analogously to Example IV, giving the product (22) as a colorless solid of molecular weight 780.76 (C44H44BrF2N3O3); MS (ESI): 700.3 (MH+).

後処理

  1. customreacted analogously to Example IV

出典と根拠

ORDレコード
ord-fd8cb57eb91a420ab2c9191a40d83c8c
出典データセット
uspto-grants-2007_02
特許番号
US07176194B2

関連ノート

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