3-(4-Benzyloxyphenyl)-2-(4-fluoro-phenoxy)-2-methyl-3-(2,2,2-trifluoroacetoxy)propionic acid ethyl ester → 2-(4-Fluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

HRID 348364ノート

反応式

HRID 348364 の反応式
[CH2:1]([O:3][C:4](=[O:37])[C:5]([O:29][C:30]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=1)([CH3:28])[CH:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20]CC2C=CC=CC=2)=[CH:16][CH:15]=1)OC(=O)C(F)(F)F)[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:37])[C:5]([O:29][C:30]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=1)([CH3:28])[CH2:6][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[CH3:2]

参加物

4

反応物 1

HCID 693537543-(4-Benzyloxyphenyl)-2-(4-fluoro-phenoxy)-2-methyl-3-(2,2,2-trifluoroacetoxy)propionic acid ethyl ester

生成物 1

HCID 693160702-(4-Fluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

3-(4-Benzyloxyphenyl)-2-(4-fluoro-phenoxy)-2-methyl-3-(2,2,2-trifluoroacetoxy)propionic acid ethyl ester (2.1 mmol) was dissolved in ethyl acetate (30 mL) and treated with 5% palladium on carbon (300 mg), and stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to an oil.

後処理

  1. filtrationThe suspension was filtered through celite and
  2. concentrationconcentrated in vacuo to an oil

出典と根拠

ORDレコード
ord-e26e9df889844e8a8d4432935cb0dbfd
出典データセット
uspto-grants-2007_02
特許番号
US07176224B2

反応ノート

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