Magnesium Chloride → HCID 178488147、化合物

HRID 348429

反応式

HRID 348429 の反応式
[K].[CH3:2][O:3][C:4]1[CH:25]=[CH:24][C:7]2[NH:8][C:9]([S@:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:10][C:6]=2[CH:5]=1.[Cl-].[Mg+2].[Cl-]>O>[CH3:23][C:17]1[CH:16]=[N:15][C:14]([CH2:13][S+:11]([O-:12])[C:9]2[NH:8][C:7]3[CH:24]=[CH:25][C:4]([O:3][CH3:2])=[CH:5][C:6]=3[N:10]=2)=[C:19]([CH3:20])[C:18]=1[O:21][CH3:22]

参加物

5

反応物 3

HCID 5360315Magnesium ChlorideHCID 5462222PotassiumHCID 9568614Esomeprazole

生成物 1

HCID 178488147HCID 178488147、化合物収率 76.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

Potassium salt of (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl) methylsulfinyl]1-H-benzimidazole (Esomeprazole potassium) (5.2 gm) was dissolved in water (75 ml). To this solution, was added magnesium chloride solution (1.4 gm in 50 ml water), and then the contents were stirred for 1 hour at 25° C. The solid precipitated was filtered, washed with water and dried under vacuum for 12 hours at 40° C. to obtain 4.0 gm of esomeprazole magnessium dihydrate (enantiomeric excess: 99.7%).

後処理

  1. customThe solid precipitated
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under vacuum for 12 hours at 40° C.

出典と根拠

ORDレコード
ord-7e116e956ae54210a4e262617ce47c1d
出典データセット
uspto-grants-2007_02
特許番号
US07176319B2

関連ノート

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