2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester

HRID 348452

反応式

HRID 348452 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[CH3:22][C:23]1[N:24]([C:29]2[C:34](O)=[CH:33][CH:32]=[CH:31][N:30]=2)[C:25]([CH3:28])=[CH:26][CH:27]=1>>[CH3:28][C:25]1[N:24]([C:29]2[C:34]([O:20][C:19](=[O:21])[CH2:18][O:17][C:14]3[N:13]=[CH:12][C:11]([C:9](=[O:10])[NH:8][C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[CH:16][N:15]=3)=[CH:33][CH:32]=[CH:31][N:30]=2)[C:23]([CH3:22])=[CH:27][CH:26]=1

参加物

3

反応物 2

HCID 27746912-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-olHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

生成物 1

HCID 69523459[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester収率 28%

実験手順

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-ol (32 mg, 0.17 mmol) as the source alcohol. Chromatographic (30–40% ethyl acetate/hexane) purification yielded 22 mg (28%) of the titled compound. ESI-MS t/z 462 (MH+), 460 (M−H−).

後処理

  1. customChromatographic (30–40% ethyl acetate/hexane) purification

出典と根拠

ORDレコード
ord-6bf752b0309a4bf8a2d5128e0253f2b9
出典データセット
uspto-grants-2007_02
特許番号
US07176310B1

関連ノート

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