Hydrochloric Acid → 3-(2-Hexyl-4-tetradecylphenoxy)-1,2-propanediol

HRID 34846ノート

反応式

HRID 34846 の反応式
[CH2:1]([C:7]1[CH:21]=[C:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:19]=[CH:18][C:8]=1[O:9][CH2:10][CH:11]1[CH2:15][O:14]C(C)(C)[O:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Cl>O1CCCC1>[CH2:1]([C:7]1[CH:21]=[C:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:19]=[CH:18][C:8]=1[O:9][CH2:10][CH:11]([OH:12])[CH2:15][OH:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 148196694-((2-Hexyl-4-tetradecylphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane

生成物 1

HCID 148196703-(2-Hexyl-4-tetradecylphenoxy)-1,2-propanediol収率 98.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 13.6 g of 4-[(2-hexyl-4-tetradecylphenoxy)methyl]-2,2-dimethyl-1,3-dioxolane, 10 ml of 5% hydrochloric acid and 250 ml of tetrahydrofuran was heated at reflux for 4 hours, then allowed to cool and the tetrahydrofuran removed under reduced pressure. The mixture was then extracted several times with ethyl acetate. The organic extracts were combined, washed with aqueous sodium bicarbonate, dried and the solvent evaporated, giving 12.3 g of the desired compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. temperatureto cool
  4. customthe tetrahydrofuran removed under reduced pressure
  5. extractionThe mixture was then extracted several times with ethyl acetate
  6. washwashed with aqueous sodium bicarbonate
  7. customdried
  8. customthe solvent evaporated

出典と根拠

ORDレコード
ord-711ef3573cc442a582daacab3d201232
出典データセット
uspto-grants-1988_08
特許番号
US04762942

反応ノート

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