Trimethyl orthoformate → Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

HRID 348524

反応式

HRID 348524 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].[CH:14](OC)(OC)OC>>[CH3:13][N:12]1[C:11]2[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=2[N:1]=[CH:14]1

参加物

3

反応物 2

HCID 9005Trimethyl orthoformateHCID 15586064Methyl 3-amino-4-(methylamino)benzoate

生成物 1

HCID 965319Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

実験手順

A solution of methyl 3-amino-4-methylaminobenzoate (prepared as in DE 1990390463 A1) (2.57 g, 14 mmol) in trimethyl orthoformate (50 mL) was refluxed for 16 hours. The solvent was then removed under reduced pressure to afford 2.31 g of product.

後処理

  1. customThe solvent was then removed under reduced pressure

出典と根拠

ORDレコード
ord-32dc8e7f00a3425182a33ced2a8f8734
出典データセット
uspto-grants-2007_02
特許番号
US07176322B2

関連ノート

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