Hydrochloric Acid → 4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic Acid

HRID 348629ノート

反応式

HRID 348629 の反応式
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:15][N:16]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:17][C:18]2[NH:19][CH:20]=[CH:21][N:22]=2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].Cl>CO>[NH:19]1[CH:20]=[CH:21][N:22]=[C:18]1[CH2:17][N:16]([CH2:15][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=1)[CH2:23][C:24]1[NH:28][CH:27]=[CH:26][N:25]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669413384-{[bis(1H-imidazol-2-ylmethyl)amino]methyl)naphthalene-1-carboxylic acid methyl ester

生成物 1

HCID 210844614-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic Acid収率 104.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound (675 mg) obtained in Example 36-3 was added with methanol (7.0 ml) and a 1 mol/l sodium hydroxide (7.0 ml), followed by stirring for 1 hour. After completion of the reaction, 1 mol/l hydrochloric acid (8.0 ml) was added to adjust the solution to pH 4. Then, the solvent was distilled off and the residue was washed with methanol, followed by drying. Consequently, the subject compound (677 mg) was obtained as a white solid.

後処理

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. washthe residue was washed with methanol
  4. customby drying

出典と根拠

ORDレコード
ord-c4553b524fea4f88ab3c073c3a13fde2
出典データセット
uspto-grants-2007_02
特許番号
US07176227B2

反応ノート

読み込み中…