1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde
反応式
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1参加物
4
実験手順
Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.
後処理
- filtrationThe reaction solution was filtrated through Celite
- distillationthe solvent was then distilled off
- customThe residue was dried under vacuum
出典と根拠
- ORDレコード
- ord-08bcf8622f984d33a60644c8f0c66571
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07176227B2
反応ノート
読み込み中…