(3-(Benzyloxy)-6-methylpyridin-2-yl)methanol → 3-(Benzyloxy)-6-methylpicolinaldehyde

HRID 349205ノート

反応式

HRID 349205 の反応式
[CH2:1]([O:8][C:9]1[C:10]([CH2:16][OH:17])=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)Cl.O=[Mn]=O>[CH3:15][C:12]1[N:11]=[C:10]([CH:16]=[O:17])[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

参加物

4

反応物 1

HCID 22711808(3-(Benzyloxy)-6-methylpyridin-2-yl)methanol

生成物 1

HCID 227117753-(Benzyloxy)-6-methylpicolinaldehyde収率 94%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3-(benzyloxy)-6-methyl-2-pyridinemethanol (0.0314 mol) and MnO2 (29.52 g) in CH2Cl2 (100 ml) was stirred at room temperature overnight and then purified over silica gel on a glass filter (eluent: CH2Cl2 100%). The pure fractions were collected and the solvent was evaporated, yielding 6.71 g of 6-methyl-3-(phenyl-methoxy)-2-pyridinecarboxaldehyde (94%) (interm. 6).

後処理

  1. custompurified over silica gel on a glass
  2. filtrationfilter (eluent: CH2Cl2 100%)
  3. customThe pure fractions were collected
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-a9eea54daab541a2990ab2ef33b2b094
出典データセット
uspto-grants-2007_02
特許番号
US07179811B2

反応ノート

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